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  1. Neuroimmunology-Munich
  2. Our Labs
  3. Single-cell Genomics

Single-cell Genomics

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edu topic

Our Aim

Multiple sclerosis is a disease affecting the central nervous system where the immune system is involved in its pathogenesis. Both the nervous and immune system represent the most daunting example of complexity in biology. Despite considerable research efforts, the knowledge and understanding of the interaction between these two complex systems and the cause of multiple sclerosis is still unknown. Gene expression analysis on bulk populations of immune cells and bulk tissue have been heretofore performed in attend to delineate the transcriptome changes in the disease. Nonetheless, in this type of analysis the differences in gene expression and variability between the different players (single cells) involved in this complex disease will remain masked.

 

Our Approach

The rapid development of single-cell analysis has revolutionized our ability to study the complexity of both the immune and nervous system at the single cell level. Individual cells are now classified by their transcriptome rather than by expression of classical cell type markers. Using state-of-the-art single-cell genomics methods, such as single-cell RNA sequencing (scRNA-seq), we identify, until now, unknown cell phenotypes and cell-cell interactions making use of unbiased bioinformatics methods. Overall, this allows us to gain deeper insights into the complexity of multiple sclerosis, as well as other complex neuroimmunological diseases.

Martin Kerschensteiner

Contact

Prof. Martin Kerschensteiner
Martin.Kerschensteiner@med.uni-muenchen.de 

Dr. Arek Kendirli

Arek.Kendirli@med.uni-muenchen.de 

We gratefully acknowledge support for our work by the following agencies:

Collaborative Research Center SFB-TR 274

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Germam Research Foundation

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Munich Cluster for Systems Neurology (SyNergy)

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ERA-Net for Research Programmes on Rare Diseases

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Merck KGaA

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Contact

Institute of Clinical Neuroimmunology
University Hospital and Biomedical Center
Ludwig-Maximilians University Munich

Director: Prof. Dr. med. Martin Kerschensteiner

Clinical Team:
Marchioninistrasse 15, 81377 Munich
Phone: +49 (0) 89 4400 74781

Research Team:
Grosshaderner Strasse 9, 82152 Martinsried
Phone: : +49 (0) 89 2180 71660

www.neuroimmunology-munich.de

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Partners

BMC – Biomedizinisches Zentrum der LMU München

Neurologische Klinik und Poliklinik der Universität München

SyNergy – Munich Cluster for Systems Neurology

GSN – Graduate School for Systemtic Neurosciences

CRC 128 – Collaborative Research Center 128

CRC 274 – Collaborative Research Center 274

CRC 870 – Collaborative Research Center 870

Verein Therapieforschung für MS-Kranke e.V.

Munich Center for Neurosciences

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