The institute of clinical neuroimmunology always welcomes spontaneous applications from motivated students at the Bachelor, Master, PhD, MD or post-doc level.
The Beltrán and Kerschensteiner Labs at the Biomedical Center of the Ludwig-Maximilians University Munich are looking for a PhD student in Bioinformatics. The candidate will develop bioinformatic methods for integrative analysis of scRNA-seq and snRNA-seq datasets from multiple sclerosis (MS) human samples and related MS models. Such integrative analysis of MS related data sets will allow us to identify and remove from the equation the species-specific or model-specific mechanisms and thereby improve the translational predictability of preclinical models and facilitate the functional interpretation of MS-related changes in the immune and nervous systems.
We are looking for highly motivated, enthusiastic and hard-working applicants with bioinformatics background, who are fluent in English. The starting date for this position is flexible, but we aim for beginning of 2020. Funding for this project is secured for 3 years. If you are interested in the position please send a letter of motivation, your CV and the names and contact details of 2 to 3 references to: Eduardo.Beltran@med.uni-muenchen.de
Dr. Eduardo Beltrán, Group Leader, Single-cell Genomics Lab, Institute of Clinical Neuroimmunology
Prof. Dr. med. Martin Kerschensteiner, Chair, Institute of Clinical Neuroimmunology
• Hiltensperger et al., Nature Immunology 22, 880–892 (2021)
• Jafari et al., Nature Neuroscience 24(3):355-367 (2021)
• Beltrán et al., Journal of Clinical Investigations 129(11):4758-4768 (2019)
• Locatelli et al., Nature Neuroscience 21:1196-1208 (2018)
PhD/Postdoc position in Neuroscience/Neuroimmunology
Are you curious about the interaction of the immune system and the brain in health and disease? We here offer a PhD or postdoc position to study the cellular and circuit mechanisms of autoimmune encephalitis. Using state-of-the-art in vivo imaging to longitudinally monitor the structure and function of different neuronal types as well as their interaction with immune cells, combined with single cell transcriptomics as well as biomarker search in collaboration with our outpatient clinic, we will explore the nature and causal role of the neuro-immune crosstalk in autoimmune encephalitis. The project will be conducted in close collaboration with the lab of Prof. Harald Prüss at the Charité and DZNE in Berlin (https://www.dzne.de/forschung/forschungsbereiche/grundlagenforschung/forschungsgruppen/pruess/forschungsschwerpunkte).
Research in the Liebscher lab (https://www.neuroimmunology-munich.de/our-labs/liebscher-lab/62208d74399bdb46) at the Institute of Neuroimmunology of the Ludwig-Maximilians University (Munich Cluster of Systems Neurology - SyNergy) is centred on the investigating of circuit mechanisms in CNS disorders, using a variety of techniques ranging from biochemical, transcriptional, proteomic and immunohistochemical approaches to behavior, cutting-edge in vivo two-photon calcium imaging and circuit tracing. We strive to gain insight into the differential vulnerability of cell-types in CNS disorders such as Amyotrophic lateral sclerosis, Alzheimer’s - , Huntington’s disease and autoimmune encephalitis and how neural networks both at micro- and macroscale are affected across disease stages to further fuel neuronal dysfunction and eventual degeneration.
Our lab is embedded within an outstanding research environment, encompassing the BioMedical Center, the University hospital, the DZNE, the SyNergy excellence cluster together with the Technical University as well as 2 Max Planck Institutes, all of which allow for access to state-of-the-art technologies, lively scientific exchange and various collaborative opportunities.
Ideal candidates should hold a degree in natural sciences, medicine, or physics with a strong background in neuroscience and have prior experience with in vivo two-photon imaging and programming. We are looking for a highly motivated team-player and ‘science geek’ to complement our international team.
Funding is secured for a minimum of 3 years for a PhD candidate and 2 years for a postdoc. Please send your application, including your CV, letter of motivation and the names and contact details of at least 2 referees as a single pdf file to: Sabine.Liebscher@med.uni-muenchen.de